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Question Are there any criteria to help differentiate between patterns of edema in infarction and tumor in the CNS?
Answer Dr. James Abrahams responds:

Edema from a met or tumor is usually in the white matter and does not involve the cortex radiographically. The gray-white (cortical-medullary) junction is therefore more easily seen on CT because the white matter becomes darker. An infarct, on the other hand, involves the cortex and causes edema of the cortex. This edema causes the cortex to become slightly darker to the point where it takes on the same color as the white matter. Thus, the gray and white matter have the same color and there is loss of the gray-white junction with an infarct. If one is dealing with a lacuna, or white matter infarct, then all bets are off. One can not differentiate this edema from a tumor and contrast should be given if there is any question of a tumor.
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