Osteosarcoma: Radiographic Features and Imaging Strategies
Prepared for RadiologyWeb by Joseph A Gagliardi, M.D.
Table of Contents
Introduction
Part 1: Intramedullary Osteosarcoma
Part 2: Surface Osteosarcoma
Part 3: Secondary Osteosarcoma
Part 4: Extraskeletal and Gnathic Osteosarcoma
References
Contributing Authors: Lustberg H1, Gagliardi JA1, Lawson JP2, Lawson AJ3, Fugate M1, Micalizzi GJ1, Specht NT1.
- Department of Radiology, St. Vincent's Medical Center, Bridgeport, CT.
- Department of Radiology, Yale University, New Haven, CT.
- Department of Radiology, Waterbury Hospital, Waterbury, CT.
Introduction
Osteosarcoma is the most common primary malignant bone neoplasm in young males and females with a peak incidence between 10 to 25 years of age [1]. Typically, osteosarcoma occurs in an intramedullary location, however, this neoplasm can also be found on the surface of the bone. It may arise within a pre-existing lesion or area of insult. Furthermore, osteosarcoma can also be found in extraskeletal locations.
Histologically, osteosarcoma is a malignant mesenchymal tumor, which can also produce chondroid or fibrous tissue; however, it is the production of osteoid and/or immature bone elements by the tumor cells, regardless of how much the latter accounts for in the total tumor volume, which allows for the diagnosis of osteosarcoma [2].
This series of articles and illustrations will consist of four parts, examining the radiologic imaging features of primary intramedullary osteosarcoma (Part 1), surface osteosarcoma (Part 2), secondary osteosarcoma (Part 3), and extraskeletal and gnathic osteosarcoma (Part 4).
Read Part 1
Read Part 2
Read Part 3
Read Part 4
References (Introduction)
1. Meyer NR, Gagliardi JA, Lawson JP. Musculoskeletal radiology. In: Practical Guide to Diagnostic Imaging. St. Louis: CV Mosby, 1998: 261.
2. Greenfield GB. The solitary lesion. In: Greenfield GB ed. Radiology of Bone Disease. 4th ed. St. Louis: J.B. Lippincott, 1986: 558-582.
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