4. For each numbered item (1-4), select the most closely associated infection.

1) Infectious agent involves the oligodendroglia
2) Predilection for endothelial cells is associated with characteristic complications
3) Most common central nervous system infection in AIDS
4) Infectious agent involves perivascular spaces

A) Cryptococcus
B) Toxoplasmosis
C) HIV encephalitis
D) Progressive multifocal leukoencephalopathy
E) Herpes simplex virus